On the Mechanism of Alloxan Hypoglycemia
نویسنده
چکیده
Intravenous injection of alloxan into rabbits, rats, dogs, monkeys, etc., produces a brief hyperglycemia, then a transient hypoglycemia, which in the case of rabbits is severe enough to cause convulsions and death, unless counteracted by repeated injections of glucose, and finally a permanent diabetic hyperglycemia. The cause of the transient hypoglycemia has had various explanations. Goldner and Gomori (1, Z), Kennedy and Lukens (3), and Banerjee (4) consider that the secondary hypoglycemia is pancreatic in origin, due to the liberation of insulin by the p cells of the islets undergoing destruction. Houssay and his associates (5), however, attribute the hypoglycemia to an extrapancreatic effect, viz., lack of glucose production by the liver. Recently, Banerjee and Bhattacharya (6) observed no hypoglycemic convulsions in rabbits fasted and phlorhizinized for a period of 7 days and then injected with diabetogenic doses of alloxan. The present paper is an extension of this study of the mechanism of alloxan hypoglycemia. The effect of the injection of diabetogenic doses of alloxan on blood sugar levels has been investigated in rabbits with yellow phosphorus liver damage, with persistent phlorhizin glycosuria, and after fasting. A comparison has also been made of the glycogen content of livers of rabbits after periods of fasting and during convulsive seizures due to injections of diabetogenic doses of alloxan or due to excessive doses of insulin.
منابع مشابه
On the Mechanism of Alloxan Hypoglycemia
Intravenous injection of alloxan into rabbits, rats, dogs, monkeys, etc., produces a brief hyperglycemia, then a transient hypoglycemia, which in the case of rabbits is severe enough to cause convulsions and death, unless counteracted by repeated injections of glucose, and finally a permanent diabetic hyperglycemia. The cause of the transient hypoglycemia has had various explanations. Goldner a...
متن کاملStudies on the mechanism of alloxan hypoglycemia.
It is well known that when alloxan is injected intravenously into rabbits, dogs, and monkeys an initial hyperglycemia is followed by a transient hypoglycemia, leading to death of the animals from hypoglycemic convulsions. If the hypoglycemia is prevented by repeated intravenous injections of glucose, the animals survive and permanent hyperglycemia and diabetes develop. The cause of the transien...
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متن کاملVentromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia.
OBJECTIVE The counterregulatory response to insulin-induced hypoglycemia is mediated by the ventromedial hypothalamus (VMH), which contains specialized glucosensing neurons, many of which use glucokinase (GK) as the rate-limiting step in glucose's regulation of neuronal activity. Since conditions associated with increased VMH GK expression are associated with a blunted counterregulatory respons...
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